Immunity Mcqs Mdcat



30 Important MCQs on Immunity for MDCAT 2026

Innate Immunity

  1. Which of the following is the first line of defense in the human body?
    A) Antibodies
    B) Skin
    C) T lymphocytes
    D) Plasma cells

Answer: B) Skin

  1. The immunity present at birth is called:
    A) Acquired immunity
    B) Passive immunity
    C) Innate immunity
    D) Artificial immunity

Answer: C) Innate immunity

  1. Which cells engulf and destroy pathogens?
    A) RBCs
    B) Neurons
    C) Phagocytes
    D) Platelets

Answer: C) Phagocytes

  1. Fever during infection is mainly caused by:
    A) Antibodies
    B) Pyrogens
    C) Histamine
    D) Hemoglobin

Answer: B) Pyrogens

  1. Inflammation is characterized by all EXCEPT:
    A) Redness
    B) Swelling
    C) Pain
    D) Low blood supply

Answer: D) Low blood supply

Adaptive Immunity

  1. Immunity developed after exposure to pathogens is called:
    A) Innate immunity
    B) Acquired immunity
    C) Genetic immunity
    D) Natural immunity

Answer: B) Acquired immunity

  1. Antibodies are produced by:
    A) T cells
    B) Plasma cells
    C) Macrophages
    D) Mast cells

Answer: B) Plasma cells

  1. The basic unit of antibody is called:
    A) Antigen
    B) Immunoglobulin
    C) Histamine
    D) Complement

Answer: B) Immunoglobulin

  1. Which immunoglobulin can cross the placenta?
    A) IgA
    B) IgD
    C) IgE
    D) IgG

Answer: D) IgG

  1. Which antibody is mainly involved in allergic reactions?
    A) IgA
    B) IgM
    C) IgE
    D) IgG

Answer: C) IgE

  1. The most abundant antibody in blood plasma is:
    A) IgM
    B) IgG
    C) IgE
    D) IgD

Answer: B) IgG

  1. Which antibody is the first to be produced during primary immune response?
    A) IgA
    B) IgE
    C) IgM
    D) IgG

Answer: C) IgM

  1. Secretions like tears and saliva mainly contain:
    A) IgA
    B) IgM
    C) IgD
    D) IgE

Answer: A) IgA

Lymphocytes & Organs

  1. T lymphocytes mature in the:
    A) Bone marrow
    B) Spleen
    C) Thymus
    D) Liver

Answer: C) Thymus

  1. B lymphocytes mature in the:
    A) Bone marrow
    B) Thymus
    C) Pancreas
    D) Spleen

Answer: A) Bone marrow

  1. Which cells are responsible for cell-mediated immunity?
    A) B cells
    B) Plasma cells
    C) T cells
    D) Mast cells

Answer: C) T cells

  1. Humoral immunity is mediated by:
    A) T cells
    B) Antibodies
    C) Platelets
    D) Neutrophils

Answer: B) Antibodies

  1. The largest lymphatic organ is the:
    A) Thymus
    B) Spleen
    C) Tonsil
    D) Appendix

Answer: B) Spleen

  1. Tonsils help in defending against pathogens entering through:
    A) Skin
    B) Blood
    C) Mouth and nose
    D) Kidneys

Answer: C) Mouth and nose

Vaccines & Immunization

  1. Vaccination provides:
    A) Natural passive immunity
    B) Artificial active immunity
    C) Natural active immunity
    D) Artificial passive immunity

Answer: B) Artificial active immunity

  1. Immunity acquired by injection of antibodies is:
    A) Active immunity
    B) Natural immunity
    C) Passive immunity
    D) Cell-mediated immunity

Answer: C) Passive immunity

  1. Edward Jenner is famous for developing the vaccine against:
    A) Polio
    B) Tuberculosis
    C) Smallpox
    D) Rabies

Answer: C) Smallpox

  1. The weakened form of pathogen used in vaccines is called:
    A) Antigen
    B) Attenuated pathogen
    C) Antibody
    D) Toxin

Answer: B) Attenuated pathogen

  1. Booster doses are given to:
    A) Destroy antibodies
    B) Enhance immune memory
    C) Reduce immunity
    D) Prevent inflammation

Answer: B) Enhance immune memory

Antigens & Immune Response

  1. A foreign substance that triggers immune response is called:
    A) Antibody
    B) Antigen
    C) Histamine
    D) Interferon

Answer: B) Antigen

  1. Memory cells are important because they:
    A) Destroy RBCs
    B) Produce hormones
    C) Provide faster secondary response
    D) Carry oxygen

Answer: C) Provide faster secondary response

  1. AIDS is caused by:
    A) Bacteria
    B) Fungus
    C) HIV
    D) Protozoa

Answer: C) HIV

  1. HIV mainly attacks:
    A) RBCs
    B) Helper T cells
    C) Platelets
    D) Neurons

Answer: B) Helper T cells

  1. Histamine is released during:
    A) Digestion
    B) Allergy and inflammation
    C) Respiration
    D) Blood clotting

Answer: B) Allergy and inflammation

  1. Interferons are proteins that help defend against:
    A) Bacteria
    B) Viruses
    C) Worms
    D) Fungi

Answer: B) Viruses

High-Yield MDCAT Tips

  • IgG → crosses placenta

  • IgA → tears, saliva, milk

  • IgE → allergy

  • IgM → first antibody formed

  • T cells → cell-mediated immunity

  • B cells → antibody production

  • Vaccination → artificial active immunity

  • Serum antibodies → artificial passive immunity

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